Yes you can use the Disk Cleanup program in the System Tools of your PC. However CCleanerdoes a better job. As mentioned it can be used to delete invalid registry entries from your computer. It is not a sophisticated program for doing this but for those unfamiliar with registry files, it will do the job without harming your computer. It also is very good for cleaner your internet browser's cookies, history, temporary files and form history and download history.
Having said all this I will add that you can customize the settings. For example should you not wish to delete anything related to MS Office you can. This is important because if you select MS Office your history of recently opened documents will be deleted.
CCleaner also removes from your PC temporary files, listing of recent documents opened and clears your recycle bin. In addition it also removes unnecessary information from various third party programs. These include MS Office and Adobe Acrobat. If you like your computer to save your passwords (not recommended) or browsing history you have that option. Should you wish not to delete selected cookies, there is an option for that as well.
You also can uninstall programs using CCleaner instead of going into your computer's Control Panel. The ability to wipe your hard drive also exists by going into the Tools option and selecting "Drive Wiper" then selecting "Entire Drive" in the drop down menu to the right of "Wipe" so you do need to exercise some caution.
In all this is a desirable program to have on your hard drive. It is free and is a good way to get rid of unneeded files as well as being user friendly. I have found the settings to be easy to use.
UPDATE: CCleaner is now available to Mac users as a free beta download. http://lifehacker.com/5808168/ccleaner-for-mac-clears-personal-data-in-one-click-for-safari-and-firefox
I would like to add here that if anyone has a suggestion for a subject, please let me know. Also please feel free to comment. All comments are welcomed.